Loss of Neoplastic Properties in [“itro II. Observations on KB Sublines'
نویسنده
چکیده
human epidermoid carcinoma (2), has been used exten sively for the bioassay of potential anti-tumor agents, particularly in laboratories participating in the screening programs of the Cancer Chemotherapy National Service Center (17). Heterotransplantation studies done in 1955 (13) and subsequently (8—11) with the KB subline then carried at The Children's Cancer Research Foundation (CCRF) showed that implantation of circa 10 cells resulted
منابع مشابه
Loss of Neoplastic Properties in /“itro. I. Observations with 5-180 Cell Lines*
origin “transform to malignancy― during serial propaga tion in vitro has received considerable attention. The converse—i.e., that cells of neoplastic origin maintained in vitro may lose their neoplastic property (or properties) consequent to serial propagation—has received little consideration, despite the fact that such events also have been recorded in the literature. Jacoby (39) desc...
متن کاملLoss of neoplastic properties in vitro. II. Observations on KB sublines.
human epidermoid carcinoma (2), has been used exten sively for the bioassay of potential anti-tumor agents, particularly in laboratories participating in the screening programs of the Cancer Chemotherapy National Service Center (17). Heterotransplantation studies done in 1955 (13) and subsequently (8—11) with the KB subline then carried at The Children's Cancer Research Foundation (CCRF) show...
متن کاملInduction of Heme Oxygenase -1 By Lipocalin 2 Mediated By Nf-Kb Transcription Factor
Purpose: Effect of lipocalin 2 on the expression of heme oxygenase I , II and NF-kB transcription factor was the purpose of this survey. Materials and Methods: Lcn2 was cloned to pcDNA3.1 plasmid by using genetic engineering method. The recombinant vector was transfected to CHO and HEK293T to establish stable cell expressing lipocalin 2. The presence of lipocalin 2 gene in these cells was confi...
متن کاملCooperative disengagement of Fas and intercellular adhesion molecule-1 function in neoplastic cells confers enhanced colonization efficiency.
Understanding the mechanisms of tumor progression is crucial toward the development of therapeutic interventions. Although the loss of sensitivity to cell death is a hallmark of neoplastic progression, it is likely one of several essential features that underlie a malignantly proficient or aggressive tumorigenic phenotype. Here, we identified intercellular adhesion molecule-1 (ICAM-1) as a mole...
متن کاملLoss of Neoplastic Properties in Vitro. I. Observations with S-180 Cell Lines.
origin “transform to malignancy― during serial propaga tion in vitro has received considerable attention. The converse—i.e., that cells of neoplastic origin maintained in vitro may lose their neoplastic property (or properties) consequent to serial propagation—has received little consideration, despite the fact that such events also have been recorded in the literature. Jacoby (39) desc...
متن کامل